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Cytochrome c oxidase response to changes in cerebral oxygen delivery in the adult brain shows higher brain-specificity than haemoglobin

Kolyva, C and Ghosh, A and Tachtsidis, I and Highton, D and Cooper, CE and Smith, M and Elwell, CE (2014) 'Cytochrome c oxidase response to changes in cerebral oxygen delivery in the adult brain shows higher brain-specificity than haemoglobin.' NeuroImage, 85. 234 - 244. ISSN 1053-8119

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Abstract

The redox state of cerebral mitochondrial cytochrome c oxidase monitored with near-infrared spectroscopy (δ[oxCCO]) is a signal with strong potential as a non-invasive, bedside biomarker of cerebral metabolic status. We hypothesised that the higher mitochondrial density of brain compared to skin and skull would lead to evidence of brain-specificity of the δ[oxCCO] signal when measured with a multi-distance near-infrared spectroscopy (NIRS) system. Measurements of δ[oxCCO] as well as of concentration changes in oxygenated (δ[HbO2]) and deoxygenated haemoglobin (δ[HHb]) were taken at multiple source-detector distances during systemic hypoxia and hypocapnia (decrease in cerebral oxygen delivery), and hyperoxia and hypercapnia (increase in cerebral oxygen delivery) from 15 adult healthy volunteers. Increasing source-detector spacing is associated with increasing light penetration depth and thus higher sensitivity to cerebral changes. An increase in δ[oxCCO] was observed during the challenges that increased cerebral oxygen delivery and the opposite was observed when cerebral oxygen delivery decreased. A consistent pattern of statistically significant increasing amplitude of the δ[oxCCO] response with increasing light penetration depth was observed in all four challenges, a behaviour that was distinctly different from that of the haemoglobin chromophores, which did not show this statistically significant depth gradient. This depth-dependence of the δ[oxCCO] signal corroborates the notion of higher concentrations of CCO being present in cerebral tissue compared to extracranial components and highlights the value of NIRS-derived δ[oxCCO] as a brain-specific signal of cerebral metabolism, superior in this aspect to haemoglobin. © 2013 Elsevier Inc.

Item Type: Article
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Science and Health > Life Sciences, School of
Depositing User: Users 161 not found.
Date Deposited: 19 Sep 2014 10:31
Last Modified: 19 Aug 2019 17:15
URI: http://repository.essex.ac.uk/id/eprint/10189

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