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Modelling Blood Flow and Metabolism in the Piglet Brain During Hypoxia-Ischaemia: Simulating Brain Energetics

Moroz, Tracy and Hapuarachchi, Tharindi and Bainbridge, Alan and Price, David and Cady, Ernest and Baer, Ether and Broad, Kevin and Ezzati, Mojgan and Thomas, David and Golay, Xavier and Robertson, Nicola J and Cooper, Chris E and Tachtsidis, Ilias (2013) Modelling Blood Flow and Metabolism in the Piglet Brain During Hypoxia-Ischaemia: Simulating Brain Energetics. In: UNSPECIFIED, ? - ?, United States.

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Abstract

We have developed a computational model to simulate hypoxia-ischaemia (HI) in the neonatal piglet brain. It has been extended from a previous model by adding the simulation of carotid artery occlusion and including pH changes in the cytoplasm. Here, simulations from the model are compared with near-infrared spectroscopy (NIRS) and phosphorus magnetic resonance spectroscopy (MRS) measurements from two piglets during HI and short-term recovery. One of these piglets showed incomplete recovery after HI, and this is modelled by considering some of the cells to be dead. This is consistent with the results from MRS and the redox state of cytochrome-c-oxidase as measured by NIRS. However, the simulations do not match the NIRS haemoglobin measurements. The model therefore predicts that further physiological changes must also be taking place if the hypothesis of dead cells is correct. © 2013 Springer Science+Business Media New York.

Item Type: Conference or Workshop Item (UNSPECIFIED)
Additional Information: Published proceedings: Advances in Experimental Medicine and Biology
Uncontrolled Keywords: Carotid Arteries; Brain; Animals; Animals, Newborn; Swine; Hypoxia-Ischemia, Brain; Disease Models, Animal; Electron Transport Complex IV; Hemoglobins; Spectroscopy, Near-Infrared; Magnetic Resonance Spectroscopy; Energy Metabolism; Oxidation-Reduction; Oxygen Consumption; Cerebrovascular Circulation; Hydrogen-Ion Concentration
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Science and Health
Faculty of Science and Health > Life Sciences, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 23 Dec 2014 11:26
Last Modified: 15 Jan 2022 00:23
URI: http://repository.essex.ac.uk/id/eprint/10210

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