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Sex-biased expression of microRNAs in Schistosoma mansoni.

Marco, Antonio and Kozomara, Ana and Hui, Jerome HL and Emery, Aidan M and Rollinson, David and Griffiths-Jones, Sam and Ronshaugen, Matthew (2013) 'Sex-biased expression of microRNAs in Schistosoma mansoni.' PLoS Negl Trop Dis, 7 (9). e2402 - ?. ISSN 1935-2735

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Abstract

Schistosomiasis is an important neglected tropical disease caused by digenean helminth parasites of the genus Schistosoma. Schistosomes are unusual in that they are dioecious and the adult worms live in the blood system. MicroRNAs play crucial roles during gene regulation and are likely to be important in sex differentiation in dioecious species. Here we characterize 112 microRNAs from adult Schistosoma mansoni individuals, including 84 novel microRNA families, and investigate the expression pattern in different sexes. By deep sequencing, we measured the relative expression levels of conserved and newly identified microRNAs between male and female samples. We observed that 13 microRNAs exhibited sex-biased expression, 10 of which are more abundant in females than in males. Sex chromosomes showed a paucity of female-biased genes, as predicted by theoretical evolutionary models. We propose that the recent emergence of separate sexes in Schistosoma had an effect on the chromosomal distribution and evolution of microRNAs, and that microRNAs are likely to participate in the sex differentiation/maintenance process.

Item Type: Article
Uncontrolled Keywords: Animals, Female, Gene Expression Regulation, High-Throughput Nucleotide Sequencing, Male, MicroRNAs, Schistosoma mansoni, Sex Factors
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Science and Health > Life Sciences, School of
Depositing User: Antonio Marco
Date Deposited: 23 Dec 2014 15:13
Last Modified: 04 Oct 2019 10:15
URI: http://repository.essex.ac.uk/id/eprint/10336

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