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The SNPMaP package for R: A framework for genome-wide association using DNA pooling on microarrays

Davis, OSP and Plomin, R and Schalkwyk, LC (2009) 'The SNPMaP package for R: A framework for genome-wide association using DNA pooling on microarrays.' Bioinformatics, 25 (2). 281 - 283. ISSN 1367-4803

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Abstract

Large-scale genome-wide association (GWA) studies using thousands of high-density SNP microarrays are becoming an essential tool in the search for loci related to heritable variation in many phenotypes. However, the cost of GWA remains beyond the reach of many researchers. Fortunately, the majority of statistical power can still be obtained by estimating allele frequencies from DNA pools, reducing the cost to that of tens, rather than thousands of arrays. We present a set of software tools for processing SNPMaP (SNP microarrays and pooling) data from CEL files to Relative Allele Scores in the rich R statistical computing environment. © 2008 The Author(s).

Item Type: Article
Subjects: Q Science > QH Natural history > QH426 Genetics
Divisions: Faculty of Science and Health > Biological Sciences, School of
Depositing User: Jim Jamieson
Date Deposited: 11 Dec 2014 13:22
Last Modified: 17 Aug 2017 17:46
URI: http://repository.essex.ac.uk/id/eprint/11014

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