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IRS-PCR-based genetic mapping of the huntingtin interacting protein gene (HIP1) on mouse Chromosome 5

Himmelbauer, Heinz and Wedemeyer, Niels and Haaf, Thomas and Wanker, Erich E and Schalkwyk, Leonard C and Lehrach, Hans (1998) 'IRS-PCR-based genetic mapping of the huntingtin interacting protein gene (HIP1) on mouse Chromosome 5.' Mammalian Genome, 9 (1). pp. 26-31. ISSN 0938-8990

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Huntington's disease (HD) is a devastating central nervous system disorder. Even though the gene responsible has been positionally cloned recently, its etiology has remained largely unclear. To investigate potential disease mechanisms, we conducted a search for binding partners of the HD-protein huntingtin. With the yeast two-hybrid system, one such interacting factor, the huntingtin interacting protein-1 (HIP-1), was identified (Wanker et al. 1997; Kalchman et al. 1997) and the human gene mapped to 7q11.2. In this paper we demonstrate the localization of the HIP1 mouse homologue (Hip1) into a previously identified region of human-mouse synteny on distal mouse Chromosome (Chr) 5, both employing an IRS-PCR-based mapping strategy and traditional fluorescent in situ hybridization (FISH) mapping.

Item Type: Article
Uncontrolled Keywords: Animals; Mice; DNA-Binding Proteins; Nerve Tissue Proteins; In Situ Hybridization, Fluorescence; Chromosome Mapping; Cloning, Molecular; Crosses, Genetic; Polymerase Chain Reaction; Polymorphism, Genetic; Cosmids; Genome
Subjects: Q Science > QH Natural history > QH426 Genetics
Divisions: Faculty of Science and Health
Faculty of Science and Health > Life Sciences, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 02 Aug 2017 13:07
Last Modified: 15 Jan 2022 00:49

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