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The inflammatory cytokines: molecular biomarkers for major depressive disorder?

Martin, Charlotte and Tansey, Katherine E and Schalkwyk, Leonard C and Powell, Timothy R (2015) 'The inflammatory cytokines: molecular biomarkers for major depressive disorder?' Biomarkers in Medicine, 9 (2). pp. 169-180. ISSN 1752-0363

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<jats:p> Cytokines are pleotropic cell signaling proteins that, in addition to their role as inflammatory mediators, also affect neurotransmitter systems, brain functionality and mood. Here we explore the potential utility of cytokine biomarkers for major depressive disorder. Specifically, we explore how genetic, transcriptomic and proteomic information relating to the cytokines might act as biomarkers, aiding clinical diagnosis and treatment selection processes. We advise future studies to investigate whether cytokine biomarkers might differentiate major depressive disorder patients from other patient groups with overlapping clinical characteristics. Furthermore, we invite future pharmacogenetic studies to investigate whether early antidepressant-induced changes to cytokine mRNA or protein levels precede behavioral changes and act as longer-term predictors of clinical antidepressant response. </jats:p>

Item Type: Article
Uncontrolled Keywords: antidepressants; biomarkers; cytokines; genetic; major depressive disorder; proteomic; transcriptomic
Subjects: Q Science > QH Natural history > QH426 Genetics
Divisions: Faculty of Science and Health
Faculty of Science and Health > Life Sciences, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 29 Oct 2014 10:24
Last Modified: 15 Jan 2022 00:41

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