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A study of intensity dependence of the auditory evoked potential (IDAEP) in medicated melancholic and non-melancholic depression

Fitzgerald, Paul B and Mellow, Tessa B and Hoy, Kate E and Segrave, Rebecca and Cooper, Nicholas R and Upton, Daniel J and Croft, Rodney J (2009) 'A study of intensity dependence of the auditory evoked potential (IDAEP) in medicated melancholic and non-melancholic depression.' Journal of Affective Disorders, 117 (3). pp. 212-216. ISSN 0165-0327

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Background: Major Depressive Disorder is widely recognised to be a heterogeneous syndrome with numerous depressive phenotypes, one of which is melancholic depression. Patients with melancholic depression exhibit treatment responses and outcomes that differ from patients with non-melancholic depression. The current study aimed to assess whether differences existed between melancholic and non-melancholic subtypes of depression, as measured by the event related potential, intensity dependence of the auditory evoked potential (IDAEP). Methods: IDAEP was assessed in 14 melancholic and 13 non-melancholic depressed subjects and 14 controls. Results: The melancholic patients had a significantly shallower IDAEP slope than the non-melancholic patients not explained by depression severity or age. Limitations: Antidepressants were taken by all patients in this study and the effect of continual use of these drugs on the IDAEP slopes has yet to be confirmed. Conclusions: These results provide support for neurobiological differences between melancholic and non-melancholic depressive subtypes. Melancholic depression may be characterized by ongoing over function of the serotonin system in spite of medication treatment. © 2009 Elsevier B.V. All rights reserved.

Item Type: Article
Uncontrolled Keywords: Intensity dependence Auditory Evoked; Potentials (IDAEP); Melancholia; Major depression
Subjects: B Philosophy. Psychology. Religion > BF Psychology
Divisions: Faculty of Science and Health
Faculty of Science and Health > Psychology, Department of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 12 Nov 2011 20:00
Last Modified: 15 Jan 2022 00:23

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