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Adjuvants are key factors for the development of future vaccines: Lessons from the Finlay adjuvant platform

Pérez, O and Romeu, B and Cabrera, O and González, E and Batista-Duharte, A and Labrada, A and Pérez, R and Reyes, LM and Ramírez, W and Sifontes, S and Fernández, N and Lastre, M (2013) 'Adjuvants are key factors for the development of future vaccines: Lessons from the Finlay adjuvant platform.' Frontiers in Immunology, 4 (DEC). ISSN 1664-3224

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Abstract

The development of effective vaccines against neglected diseases, especially those associated with poverty and social deprivation, is urgently needed. Modern vaccine technologies and a better understanding of the immune response have provided scientists with the tools for rational and safer design of subunit vaccines. Often, however, subunit vaccines do not elicit strong immune responses, highlighting the need to incorporate better adjuvants; this step therefore becomes a key factor for vaccine development. In this review we outline some key features of modern vaccinology that are linked with the development of better adjuvants. In line with the increased desire to obtain novel adjuvants for future vaccines, the Finlay Adjuvant Platform offers a novel approach for the development of new and effective adjuvants. The Finlay Adjuvants (AFs), AFPL (proteoliposome), and AFCo (cochleate), were initially designed for parenteral and mucosal applications, and constitute potent adjuvants for the induction of Th1 responses against several antigens. This review summarizes the status of the Finlay technology in producing promising adjuvants for unsolved-vaccine diseases including mucosal approaches and therapeutic vaccines. Ideas related to adjuvant classification, adjuvant selection, and their possible influence on innate recognition via multiple toll-like receptors are also discussed. © 2013 Pérez, Romeu, Cabrera, González, Batista-Duharte, Labrada, Pérez, Reyes, Ramírez, Sifontes, Fernández and Lastre.

Item Type: Article
Subjects: Q Science > QR Microbiology > QR180 Immunology
Divisions: Faculty of Science and Health > Life Sciences, School of
Depositing User: Jim Jamieson
Date Deposited: 10 Feb 2015 12:42
Last Modified: 07 Sep 2019 00:15
URI: http://repository.essex.ac.uk/id/eprint/12779

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