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Point-process nonlinear autonomic assessment of depressive states in bipolar patients

Valenza, G and Citi, L and Gentili, C and Lanatá, A and Scilingo, EP and Barbieri, R (2014) 'Point-process nonlinear autonomic assessment of depressive states in bipolar patients.' Methods of Information in Medicine, 53 (4). 296 - 302. ISSN 0026-1270

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Introduction: This article is part of the Focus Theme of Methods of Information in Medicine on "Biosignal Interpretation: Advanced Methods for Studying Cardiovascular and Respiratory Systems". Objectives: The goal of this work is to apply a computational methodology able to characterize mood states in bipolar patients through instantaneous analysis of heartbeat dynamics. Methods: A Point-Process-based Nonlinear Autoregressive Integrative (NARI) model is applied to analyze data collected from five bipolar patients (two males and three females, age 42.4 ± 10.5 range 32 -56) undergoing a dedicated affective elicitation protocol using images from the International Affective Picture System (IAPS) and Thematic Apperception Test (TAT). The study was designed within the European project PSYCHE (Personalised monitoring SYstems for Care in mental HEalth). Results: Results demonstrate that the inclusion of instantaneous higher order spectral (HOS) features estimated from the NARI nonlinear assessment significantly improves the accuracy in successfully recognizing specific mood states such as euthymia and depres -sion with respect to results using only linear indices. In particular, a specificity of 74.44% using the instantaneous linear features set, and 99.56% using also the nonlinear feature set were achieved. Moreover, IAPS emotional elicitation resulted in a more discriminant procedure with respect to the TAT elicitation protocol. Conclusions: A significant pattern of in-stantaneous heartbeat features was found in depressive and euthymic states despite the inter-subject variability. The presented point-process Heart Rate Variability (HRV) non -linear methodology provides a promising application in the field of mood assessment in bipolar patients. © Schattauer 2014.

Item Type: Article
Subjects: Q Science > QA Mathematics > QA75 Electronic computers. Computer science
R Medicine > R Medicine (General)
Divisions: Faculty of Science and Health > Computer Science and Electronic Engineering, School of
Depositing User: Jim Jamieson
Date Deposited: 16 Jul 2015 11:08
Last Modified: 05 Feb 2019 19:15

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