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Molecular modelling of S1 and S2 subunits of SARS coronavirus spike glycoprotein

Spiga, O and Bernini, A and Ciutti, A and Chiellini, S and Menciassi, N and Finetti, F and Causarono, V and Anselmi, F and Prischi, F and Niccolai, N (2003) 'Molecular modelling of S1 and S2 subunits of SARS coronavirus spike glycoprotein.' Biochemical and Biophysical Research Communications, 310 (1). 78 - 83. ISSN 0006-291X

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Abstract

The S1 and S2 subunits of the spike glycoprotein of the coronavirus which is responsible for the severe acute respiratory syndrome (SARS) have been modelled, even though the corresponding amino acid sequences were not suitable for tertiary structure predictions with conventional homology and/or threading procedures. An indirect search for a protein structure to be used as a template for 3D m odelling has been performed on the basis of the genomic organisation similarity generally exhibited by coronaviruses. The crystal structure of Clostridium botulinum neurotoxin B appeared to be structurally adaptable to human and canine coronavirus spike protein sequences and it was successfully used to model the two subunits of SARS coronavirus spike glycoprotein. The overall shape and the surface hydrophobicity of the two subunits in the obtained models suggest the localisation of the most relevant regions for their activity. © 2003 Elsevier Inc. All rights reserved.

Item Type: Article
Subjects: Q Science > Q Science (General)
Divisions: Faculty of Science and Health > Biological Sciences, School of
Depositing User: Filippo Prischi
Date Deposited: 04 Feb 2016 13:03
Last Modified: 01 Nov 2017 06:15
URI: http://repository.essex.ac.uk/id/eprint/14827

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