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Tertiary structure prediction of SARS coronavirus helicase

Bernini, Andrea and Spiga, Ottavia and Venditti, Vincenzo and Prischi, Filippo and Bracci, Luisa and Huang, Jiandong and Tanner, Julian A and Niccolai, Neri (2006) 'Tertiary structure prediction of SARS coronavirus helicase.' Biochemical and Biophysical Research Communications, 343 (4). pp. 1101-1104. ISSN 0006-291X

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SARS coronavirus, SCV, has been recently responsible of a sudden and widespread infection which caused almost 800 victims. The limited amount of SCV protein structural information is partially responsible of the lack of specific drugs against the virus. Coronavirus helicases are very conserved and peculiar proteins which have been proposed as suitable targets for antiviral drugs, such as bananins, which have been recently shown to inhibit the SCV helicase in vitro. Here, the quaternary structure of SCV helicase has been predicted, which will provide a solid foundation for the rational design of other antiviral helicase inhibitors. © 2006 Elsevier Inc. All rights reserved.

Item Type: Article
Uncontrolled Keywords: SARS coronavirus; protein structure; structure prediction; molecular modeling; helicase structure; drug design
Subjects: Q Science > Q Science (General)
Divisions: Faculty of Science and Health
Faculty of Science and Health > Life Sciences, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 04 Feb 2016 12:52
Last Modified: 18 Aug 2022 11:31

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