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Tertiary structure prediction of SARS coronavirus helicase

Bernini, A and Spiga, O and Venditti, V and Prischi, F and Bracci, L and Huang, J and Tanner, JA and Niccolai, N (2006) 'Tertiary structure prediction of SARS coronavirus helicase.' Biochemical and Biophysical Research Communications, 343 (4). 1101 - 1104. ISSN 0006-291X

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Abstract

SARS coronavirus, SCV, has been recently responsible of a sudden and widespread infection which caused almost 800 victims. The limited amount of SCV protein structural information is partially responsible of the lack of specific drugs against the virus. Coronavirus helicases are very conserved and peculiar proteins which have been proposed as suitable targets for antiviral drugs, such as bananins, which have been recently shown to inhibit the SCV helicase in vitro. Here, the quaternary structure of SCV helicase has been predicted, which will provide a solid foundation for the rational design of other antiviral helicase inhibitors. © 2006 Elsevier Inc. All rights reserved.

Item Type: Article
Subjects: Q Science > Q Science (General)
Depositing User: Filippo Prischi
Date Deposited: 04 Feb 2016 12:52
Last Modified: 01 Aug 2019 13:20
URI: http://repository.essex.ac.uk/id/eprint/14835

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