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Sex-Specific Effects of Adiponectin on Carotid Intima-Media Thickness and Incident Cardiovascular Disease

Persson, J and Strawbridge, RJ and McLeod, O and Gertow, K and Silveira, A and Baldassarre, D and Van Zuydam, N and Shah, S and Fava, C and Gustafsson, S and Veglia, F and Sennblad, B and Larsson, M and Sabater-Lleal, M and Leander, K and Gigante, B and Tabak, A and Kivimaki, M and Kauhanen, J and Rauramaa, R and Smit, AJ and Mannarino, E and Giral, P and Humphries, SE and Tremoli, E and de Faire, U and Lind, L and Ingelsson, E and Hedblad, B and Melander, O and Kumari, M and Hingorani, A and Morris, AD and Palmer, CNA and Lundman, P and Öhrvik, J and Söderberg, S and Hamsten, A (2015) 'Sex-Specific Effects of Adiponectin on Carotid Intima-Media Thickness and Incident Cardiovascular Disease.' Journal of the American Heart Association, 4 (8). e001853 - ?. ISSN 2047-9980

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Abstract

© 2015 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell. BACKGROUND: Plasma adiponectin levels have previously been inversely associated with carotid intima-media thickness (IMT), a marker of subclinical atherosclerosis. In this study, we used a sex-stratified Mendelian randomization approach to investigate whether adiponectin has a causal protective influence on IMT.METHODS AND RESULTS: Baseline plasma adiponectin concentration was tested for association with baseline IMT, IMT progression over 30 months, and occurrence of cardiovascular events within 3 years in 3430 participants (women, n=1777; men, n=1653) with high cardiovascular risk but no prevalent disease. Plasma adiponectin levels were inversely associated with baseline mean bifurcation IMT after adjustment for established risk factors (β=-0.018, P<0.001) in men but not in women (β=-0.006, P=0.185; P for interaction=0.061). Adiponectin levels were inversely associated with progression of mean common carotid IMT in men (β=-0.0022, P=0.047), whereas no association was seen in women (0.0007, P=0.475; P for interaction=0.018). Moreover, we observed that adiponectin levels were inversely associated with coronary events in women (hazard ratio 0.57, 95% CI 0.37 to 0.87) but not in men (hazard ratio 0.82, 95% CI 0.54 to 1.25). A gene score of adiponectin-raising alleles in 6 loci, reported recently in a large multi-ethnic meta-analysis, was inversely associated with baseline mean bifurcation IMT in men (β=-0.0008, P=0.004) but not in women (β=-0.0003, P=0.522; P for interaction=0.007).CONCLUSIONS: This report provides some evidence for adiponectin protecting against atherosclerosis, with effects being confined to men; however, compared with established cardiovascular risk factors, the effect of plasma adiponectin was modest. Further investigation involving mechanistic studies is warranted.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Social Sciences > Institute for Social and Economic Research
Depositing User: Jim Jamieson
Date Deposited: 25 Sep 2015 09:15
Last Modified: 04 Feb 2019 11:17
URI: http://repository.essex.ac.uk/id/eprint/15062

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