Research Repository

Refractory depression: Mechanisms and evaluation of radically open dialectical behaviour therapy (RO-DBT) [REFRAMED]: Protocol for randomised trial

Lynch, TR and Whalley, B and Hempel, RJ and Byford, S and Clarke, P and Clarke, S and Kingdon, D and O'Mahen, H and Russell, IT and Shearer, J and Stanton, M and Swales, M and Watkins, A and Remington, B (2015) 'Refractory depression: Mechanisms and evaluation of radically open dialectical behaviour therapy (RO-DBT) [REFRAMED]: Protocol for randomised trial.' BMJ Open, 5 (7). ISSN 2044-6055

[img]
Preview
Text
BMJ Open-2015-Lynch-.pdf - Published Version

Download (1MB) | Preview

Abstract

Introduction: Only 30-40% of depressed patients treated with medication achieve full remission. Studies that change medication or augment it by psychotherapy achieve only limited benefits, in part because current treatments are not designed for chronic and complex patients. Previous trials have excluded high-risk patients and those with comorbid personality disorder. Radically Open Dialectical Behaviour Therapy (RO-DBT) is a novel, transdiagnostic treatment for disorders of emotional over-control. The REFRAMED trial aims to evaluate the effectiveness and cost-effectiveness of RO-DBT for patients with treatment-resistant depression. Methods and analysis: REFRAMED is a multicentre randomised controlled trial, comparing 7 months of individual and group RO-DBT treatment with treatment as usual (TAU). Our primary outcome measure is depressive symptoms 12 months after randomisation. We shall estimate the cost-effectiveness of RO-DBT by cost per quality-adjusted life year. Causal analyses will explore the mechanisms by which RO-DBT is effective. Ethics and dissemination: The National Research Ethics Service (NRES) Committee South Central - Southampton A first granted ethical approval on 20 June 2011, reference number 11/SC/0146.

Item Type: Article
Subjects: R Medicine > RA Public aspects of medicine > RA790 Mental Health
Divisions: Faculty of Social Sciences > Institute for Social and Economic Research
Depositing User: Jim Jamieson
Date Deposited: 25 Sep 2015 09:54
Last Modified: 17 Aug 2017 17:32
URI: http://repository.essex.ac.uk/id/eprint/15065

Actions (login required)

View Item View Item