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Job Strain and the Risk of Stroke

Fransson, Eleonor I and Nyberg, Solja T and Heikkilä, Katriina and Alfredsson, Lars and Bjorner, Jakob B and Borritz, Marianne and Burr, Hermann and Dragano, Nico and Geuskens, Goedele A and Goldberg, Marcel and Hamer, Mark and Hooftman, Wendela E and Houtman, Irene L and Joensuu, Matti and Jokela, Markus and Knutsson, Anders and Koskenvuo, Markku and Koskinen, Aki and Kumari, Meena and Leineweber, Constanze and Lunau, Thorsten and Madsen, Ida EH and Hanson, Linda L Magnusson and Nielsen, Martin L and Nordin, Maria and Oksanen, Tuula and Pentti, Jaana and Pejtersen, Jan H and Rugulies, Reiner and Salo, Paula and Shipley, Martin J and Steptoe, Andrew and Suominen, Sakari B and Theorell, Töres and Toppinen-Tanner, Salla and Vahtera, Jussi and Virtanen, Marianna and Väänänen, Ari and Westerholm, Peter JM and Westerlund, Hugo and Zins, Marie and Britton, Annie and Brunner, Eric J and Singh-Manoux, Archana and Batty, G David and Kivimäki, Mika (2015) 'Job Strain and the Risk of Stroke.' Stroke, 46 (2). 557 - 559. ISSN 0039-2499

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<jats:sec> <jats:title>Background and Purpose—</jats:title> <jats:p>Psychosocial stress at work has been proposed to be a risk factor for cardiovascular disease. However, its role as a risk factor for stroke is uncertain.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods—</jats:title> <jats:p>We conducted an individual-participant-data meta-analysis of 196 380 males and females from 14 European cohort studies to investigate the association between job strain, a measure of work-related stress, and incident stroke.</jats:p> </jats:sec> <jats:sec> <jats:title>Results—</jats:title> <jats:p>In 1.8 million person-years at risk (mean follow-up 9.2 years), 2023 first-time stroke events were recorded. The age- and sex-adjusted hazard ratio for job strain relative to no job strain was 1.24 (95% confidence interval, 1.05;1.47) for ischemic stroke, 1.01 (95% confidence interval, 0.75;1.36) for hemorrhagic stroke, and 1.09 (95% confidence interval, 0.94;1.26) for overall stroke. The association with ischemic stroke was robust to further adjustment for socioeconomic status.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusion—</jats:title> <jats:p>Job strain may be associated with an increased risk of ischemic stroke, but further research is needed to determine whether interventions targeting job strain would reduce stroke risk beyond existing preventive strategies.</jats:p> </jats:sec>

Item Type: Article
Subjects: H Social Sciences > H Social Sciences (General)
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Divisions: Faculty of Social Sciences > Institute for Social and Economic Research
Depositing User: Jim Jamieson
Date Deposited: 25 Sep 2015 10:13
Last Modified: 13 Jul 2021 19:15

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