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Electrostatic effect of H1-histone protein binding on nucleosome repeat length

Cherstvy, Andrey G and Teif, Vladimir B (2014) 'Electrostatic effect of H1-histone protein binding on nucleosome repeat length.' Physical Biology, 11 (4). 044001-044001. ISSN 1478-3967

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Within a simple biophysical model we describe the effect of electrostatic binding of H1 histone proteins on the nucleosome repeat length in chromatin. The length of wrapped DNA optimizes its binding energy to the histone core and the elastic energy penalty of DNA wrapping. The magnitude of the effect predicted from our model is in agreement with the systematic experimental data on the linear variation of nucleosome repeat lengths with H1/nucleosome ratio (Woodcock C L et al 2006 Chromos. Res. 14 17-25). We compare our model to the data for different cell types and organisms, with a widely varying ratio of bound H1 histones per nucleosome. We underline the importance of this non-specific histone-DNA charge-balance mechanism in regulating the positioning of nucleosomes and the degree of compaction of chromatin fibers in eukaryotic cells. © 2014 IOP Publishing Ltd.

Item Type: Article
Uncontrolled Keywords: electrostatics; DNA; nucleosome
Subjects: Q Science > Q Science (General)
Q Science > QC Physics
Divisions: Faculty of Science and Health
Faculty of Science and Health > Life Sciences, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 22 Oct 2015 11:51
Last Modified: 15 Jan 2022 00:47

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