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The E3 ubiquitin ligase activity of RING1B is not essential for early mouse development

Illingworth, RS and Moffat, M and Mann, AR and Read, D and Hunter, CJ and Pradeepa, MM and Adams, IR and Bickmore, WA (2015) 'The E3 ubiquitin ligase activity of RING1B is not essential for early mouse development.' Genes and Development, 29 (18). 1897 - 1902. ISSN 0890-9369

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© 2015 Illingworth et al. Polycomb-repressive complex 1 (PRC1) and PRC2 maintain repression atmanydevelopmental genes inmouseembryonic stem cells and are required for early development. However, it is still unclear how they are targeted and how they function. We show that the ability of RING1B, a core component of PRC1, to ubiquitinate histone H2A is dispensable for early mouse embryonic development and muchof thegene repression activity ofPRC1.Ourdata support a model in which PRC1 and PRC2 reinforce each other’s binding but suggest that the key functions of PRC1 lie beyond the enzymatic capabilities of RING1B.

Item Type: Article
Subjects: Q Science > QH Natural history > QH426 Genetics
Divisions: Faculty of Science and Health > Biological Sciences, School of
Depositing User: Jim Jamieson
Date Deposited: 23 Nov 2015 10:40
Last Modified: 30 Jan 2019 16:19

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