Research Repository

The E3 ubiquitin ligase activity of RING1B is not essential for early mouse development

Illingworth, Robert S and Moffat, Michael and Mann, Abigail R and Read, David and Hunter, Chris J and Pradeepa, Madapura M and Adams, Ian R and Bickmore, Wendy A (2015) 'The E3 ubiquitin ligase activity of RING1B is not essential for early mouse development.' Genes & Development, 29 (18). pp. 1897-1902. ISSN 0890-9369

Genes Dev.-2015-Illingworth-1897-902.pdf - Published Version
Available under License Creative Commons Attribution.

Download (1MB) | Preview


<jats:p>Polycomb-repressive complex 1 (PRC1) and PRC2 maintain repression at many developmental genes in mouse embryonic stem cells and are required for early development. However, it is still unclear how they are targeted and how they function. We show that the ability of RING1B, a core component of PRC1, to ubiquitinate histone H2A is dispensable for early mouse embryonic development and much of the gene repression activity of PRC1. Our data support a model in which PRC1 and PRC2 reinforce each other's binding but suggest that the key functions of PRC1 lie beyond the enzymatic capabilities of RING1B.</jats:p>

Item Type: Article
Uncontrolled Keywords: PRC1; histone ubiquitination; H3K27me3; embryonic stem cell; Polycomb
Subjects: Q Science > QH Natural history > QH426 Genetics
Divisions: Faculty of Science and Health
Faculty of Science and Health > Life Sciences, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 23 Nov 2015 10:40
Last Modified: 14 Apr 2022 15:29

Actions (login required)

View Item View Item