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fMRI evidence that precision ophthalmic tints reduce cortical hyperactivation in migraine

Huang, Jie and Zong, Xiaopeng and Wilkins, Arnold and Jenkins, Brian and Bozoki, Andrea and Cao, Yue (2011) 'fMRI evidence that precision ophthalmic tints reduce cortical hyperactivation in migraine.' Cephalalgia, 31 (8). pp. 925-936. ISSN 0333-1024

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Abstract

Background: Certain patterns can induce perceptual illusions/distortions and visual discomfort in most people, headaches in patients with migraine, and seizures in patients with photosensitive epilepsy. Visual stimuli are common triggers for migraine attacks, possibly because of a hyperexcitability of the visual cortex shown in patients with migraine. Precision ophthalmic tints (POTs) are claimed to reduce perceptual distortions and visual discomfort and to prevent migraine headaches in some patients. We report an fMRI visual cortical activation study designed to investigate neurological mechanisms for the beneficial effects of POTs in migraine. Methods: Eleven migraineurs and 11 age- and sex-matched non-headache controls participated in the study using non-stressful and stressful striped patterns viewed through gray, POT, and control coloured lenses. Results: For all lenses, controls and migraineurs did not differ in their response to the non-stressful patterns. When the migraineurs wore gray lenses or control coloured lenses, the stressful pattern resulted in activation that was greater than in the controls. There was also an absence of the characteristic low-pass spatial frequency (SF) tuning in extrastriate visual areas. When POTs were worn, however, both cortical activation and SF tuning were normalized. Both when observing the stressful pattern and under more typical viewing conditions, the POTs reduced visual discomfort more than either of the other two lenses. Conclusion: The normalization of cortical activation and SF tuning in the migraineurs by POTs suggests a neurological basis for the therapeutic effect of these lenses in reducing visual cortical hyperactivation in migraine.

Item Type: Article
Uncontrolled Keywords: fMRI migraine precision ophthalmic tints visual cortical hyperactivation
Subjects: B Philosophy. Psychology. Religion > BF Psychology
Divisions: Faculty of Science and Health > Psychology, Department of
Depositing User: Jim Jamieson
Date Deposited: 21 Nov 2011 14:07
Last Modified: 02 Feb 2012 15:18
URI: http://repository.essex.ac.uk/id/eprint/1550

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