Romei, Vincenzo and Bauer, Markus and Brooks, Joseph L and Economides, Marcos and Penny, Will and Thut, Gregor and Driver, Jon and Bestmann, Sven (2016) 'Causal evidence that intrinsic beta-frequency is relevant for enhanced signal propagation in the motor system as shown through rhythmic TMS.' NeuroImage, 126. pp. 120-130. ISSN 1053-8119
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Abstract
Correlative evidence provides support for the idea that brain oscillations underpin neural computations. Recent work using rhythmic stimulation techniques in humans provide causal evidence but the interactions of these external signals with intrinsic rhythmicity remain unclear. Here, we show that sensorimotor cortex follows externally applied rhythmic TMS (rTMS) stimulation in the beta-band but that the elicited responses are strongest at the intrinsic individual beta peak frequency. While these entrainment effects are of short duration, even subthreshold rTMS pulses propagate through the network and elicit significant cortico-spinal coupling, particularly when stimulated at the individual beta-frequency.Our results show that externally enforced rhythmicity interacts with intrinsic brain rhythms such that the individual peak frequency determines the effect of rTMS. The observed downstream spinal effect at the resonance frequency provides evidence for the causal role of brain rhythms for signal propagation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Hand; Motor Cortex; Pyramidal Tracts; Humans; Electroencephalography; Beta Rhythm; Electromyography; Motor Activity; Evoked Potentials, Motor; Time Factors; Adult; Female; Male; Transcranial Magnetic Stimulation; Young Adult |
| Subjects: | B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
| Divisions: | Faculty of Science and Health Faculty of Science and Health > Psychology, Department of |
| SWORD Depositor: | Elements |
| Depositing User: | Elements |
| Date Deposited: | 20 Nov 2015 14:39 |
| Last Modified: | 15 Jan 2022 00:31 |
| URI: | http://repository.essex.ac.uk/id/eprint/15503 |
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