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Cytochromes c′: Structure, Reactivity and Relevance to Haem-Based Gas Sensing

Hough, MA and Andrew, CR (2015) 'Cytochromes c′: Structure, Reactivity and Relevance to Haem-Based Gas Sensing.' 1 - 84. ISSN 0065-2911

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Cytochromes c′ are a group of class IIa cytochromes with pentacoordinate haem centres and are found in photosynthetic, denitrifying and methanotrophic bacteria. Their function remains unclear, although roles in nitric oxide (NO) trafficking during denitrification or in cellular defence against nitrosoative stress have been proposed. Cytochromes c′ are typically dimeric with each c-type haem-containing monomer folding as a four-α-helix bundle. Their hydrophobic and crowded distal sites impose severe restrictions on the binding of distal ligands, including diatomic gases. By contrast, NO binds to the proximal haem face in a similar manner to that of the eukaryotic NO sensor, soluble guanylate cyclase and bacterial analogues. In this review, we focus on how structural features of cytochromes c′ influence haem spectroscopy and reactivity with NO, CO and O2. We also discuss the relevance of cytochrome c′ to understanding the mechanisms of gas binding to haem-based sensor proteins.

Item Type: Article
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Science and Health > Life Sciences, School of
Depositing User: Mike Hough
Date Deposited: 01 Dec 2015 10:02
Last Modified: 22 Jun 2021 23:15

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