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UPR Signal Activation by Luminal Sensor Domains

Carrara, Marta and Prischi, Filippo and Ali, Maruf (2013) 'UPR Signal Activation by Luminal Sensor Domains.' International Journal of Molecular Sciences, 14 (3). pp. 6454-6466. ISSN 1661-6596

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Abstract

The unfolded protein response (UPR) is a cell-signaling system that detects the accumulation of unfolded protein within the endoplasmic reticulum (ER) and initiates a number of cellular responses to restore ER homeostasis. The presence of unfolded protein is detected by the ER-luminal sensor domains of the three UPR-transducer proteins IRE1, PERK, and ATF6, which then propagate the signal to the cytosol. In this review, we discuss the various mechanisms of action that have been proposed on how the sensor domains detect the presence of unfolded protein to activate downstream UPR signaling. © 2013 by the authors; licensee MDPI, Basel, Switzerland.

Item Type: Article
Uncontrolled Keywords: unfolded protein response; ER-stress; signaling
Subjects: Q Science > Q Science (General)
Divisions: Faculty of Science and Health
Faculty of Science and Health > Life Sciences, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 15 Jan 2016 14:12
Last Modified: 18 Aug 2022 11:31
URI: http://repository.essex.ac.uk/id/eprint/15856

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