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UPR signal activation by luminal sensor domains

Carrara, M and Prischi, F and Ali, MMU (2013) 'UPR signal activation by luminal sensor domains.' International Journal of Molecular Sciences, 14 (3). 6454 - 6466. ISSN 1661-6596

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The unfolded protein response (UPR) is a cell-signaling system that detects the accumulation of unfolded protein within the endoplasmic reticulum (ER) and initiates a number of cellular responses to restore ER homeostasis. The presence of unfolded protein is detected by the ER-luminal sensor domains of the three UPR-transducer proteins IRE1, PERK, and ATF6, which then propagate the signal to the cytosol. In this review, we discuss the various mechanisms of action that have been proposed on how the sensor domains detect the presence of unfolded protein to activate downstream UPR signaling. © 2013 by the authors; licensee MDPI, Basel, Switzerland.

Item Type: Article
Subjects: Q Science > Q Science (General)
Divisions: Faculty of Science and Health > Life Sciences, School of
Depositing User: Filippo Prischi
Date Deposited: 15 Jan 2016 14:12
Last Modified: 14 Oct 2019 17:20

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