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Macromolecular iron-chelators via RAFT-polymerization for the inhibition of methicillin-resistant Staphylococcus aureus growth

Li, J and Olaleye, ED and Kong, X and Zhou, T and Ma, Y and Jurach, J and Al Rugaie, O and Hider, RC and Zhang, G and Alsam, S and Abbate, V (2016) 'Macromolecular iron-chelators via RAFT-polymerization for the inhibition of methicillin-resistant Staphylococcus aureus growth.' Polymer, 87. 64 - 72. ISSN 0032-3861

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Abstract

A series of linear poly (glycidyl methacrylate) (PGMA) polymers were synthesized via RAFT polymerization and conjugated with amine-containing 3-hydroxypyridin-4-ones (HPOs) to generate a panel of HPO-containing materials with controlled structures and specific iron-binding functions. The structures of the resulting polymers were characterized via 1 H NMR, GPC and FT-IR and their chelating capacity for iron was investigated using UV-Vis spectrophotometric titration of the iron(III) complexes. In vitro antimicrobial studies of selected ligand-containing homopolymers demonstrate that the homopolymers are capable of inhibiting the growth of methicillin-resistant Staphylococcus aureus (MRSA). It is proposed that the inhibition activity of MRSA is derived from the iron-chelating capability of the iron-binding polymers.

Item Type: Article
Uncontrolled Keywords: MRSA, Hydroxypyridinones, Iron-binding polymers
Subjects: Q Science > QH Natural history > QH301 Biology
Depositing User: Jim Jamieson
Date Deposited: 08 Feb 2016 11:54
Last Modified: 01 Aug 2019 13:17
URI: http://repository.essex.ac.uk/id/eprint/16036

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