Metodieva, Gergana and Adoki, Samson and Lausen, Berthold and Metodiev, Metodi V (2016) 'Decreased Usage of Specific Scrib Exons Defines a More Malignant Phenotype of Breast Cancer With Worsened Survival.' EBioMedicine, 8. pp. 150-158. ISSN 2352-3964

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Abstract

SCRIB is a polarity regulator known to be abnormally expressed in cancer at the protein level. Here we report that, in breast cancer, an additional and hidden dimension of deregulations exists: an unexpected SCRIB exon usage pattern appears to mark a more malignant tumor phenotype and significantly correlates with survival. Conserved exons encoding the leucine-rich repeats tend to be overexpressed while others are underused. Mechanistic studies revealed that the underused exons encode part of the protein necessary for interaction with Vimentin and Numa1, a protein which is required for proper positioning of the mitotic spindle. Thus, the inclusion/exclusion of specific SCRIB exons is a mechanistic hallmark of breast cancer, which could potentially be exploited to develop more efficient diagnostics and therapies.

Item Type:	Article
Uncontrolled Keywords:	SCRIB; Breast cancer; Splicing; Survival; Mitosis; Polarity
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions:	Faculty of Science and Health Faculty of Science and Health > Life Sciences, School of Faculty of Science and Health > Mathematical Sciences, Department of
SWORD Depositor:	Elements
Depositing User:	Elements
Date Deposited:	24 May 2016 14:51
Last Modified:	15 Jan 2022 00:45
URI:	http://repository.essex.ac.uk/id/eprint/16643

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