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Application of Nuclear Magnetic Resonance and Hybrid Methods to Structure Determination of Complex Systems

Prischi, Filippo and Pastore, Annalisa (2016) 'Application of Nuclear Magnetic Resonance and Hybrid Methods to Structure Determination of Complex Systems.' ADVANCED TECHNOLOGIES FOR PROTEIN COMPLEX PRODUCTION AND CHARACTERIZATION, 896. pp. 351-368. ISSN 0065-2598

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Abstract

The current main challenge of Structural Biology is to undertake the structure determination of increasingly complex systems in the attempt to better understand their biological function. As systems become more challenging, however, there is an increasing demand for the parallel use of more than one independent technique to allow pushing the frontiers of structure determination and, at the same time, obtaining independent structural validation. The combination of different Structural Biology methods has been named hybrid approaches. The aim of this review is to critically discuss the most recent examples and new developments that have allowed structure determination or experimentally-based modelling of various molecular complexes selecting them among those that combine the use of nuclear magnetic resonance and small angle scattering techniques. We provide a selective but focused account of some of the most exciting recent approaches and discuss their possible further developments.

Item Type: Article
Uncontrolled Keywords: Multidomain proteins; NMR; Protein-protein interactions; Structural biology; SAXS
Subjects: Q Science > Q Science (General)
Divisions: Faculty of Science and Health
Faculty of Science and Health > Life Sciences, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 12 May 2016 13:58
Last Modified: 18 Aug 2022 11:17
URI: http://repository.essex.ac.uk/id/eprint/16665

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