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Application of nuclear magnetic resonance and hybrid methods to structure determination of complex systems

Prischi, F and Pastore, A (2016) 'Application of nuclear magnetic resonance and hybrid methods to structure determination of complex systems.' 351 - 368. ISSN 0065-2598

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Abstract

© Springer International Publishing Switzerland 2016. The current main challenge of Structural Biology is to undertake the structure determination of increasingly complex systems in the attempt to better understand their biological function. As systems become more challenging, however, there is an increasing demand for the parallel use of more than one independent technique to allow pushing the frontiers of structure determination and, at the same time, obtaining independent structural validation. The combination of different Structural Biology methods has been named hybrid approaches. The aim of this review is to critically discuss the most recent examples and new developments that have allowed structure determination or experimentally-based modelling of various molecular complexes selecting them among those that combine the use of nuclear magnetic resonance and small angle scattering techniques. We provide a selective but focused account of some of the most exciting recent approaches and discuss their possible further developments.

Item Type: Article
Subjects: Q Science > Q Science (General)
Divisions: Faculty of Science and Health > Biological Sciences, School of
Depositing User: Filippo Prischi
Date Deposited: 12 May 2016 13:58
Last Modified: 17 Aug 2017 17:27
URI: http://repository.essex.ac.uk/id/eprint/16665

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