Research Repository

Receptor activity-modifying proteins; multifunctional G protein-coupled receptor accessory proteins

Hay, Debbie L and Walker, Christopher S and Gingell, Joseph J and Ladds, Graham and Reynolds, Christopher A and Poyner, David R (2016) 'Receptor activity-modifying proteins; multifunctional G protein-coupled receptor accessory proteins.' Biochemical Society Transactions, 44 (2). 568 - 573. ISSN 0300-5127

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Receptor activity-modifying proteins (RAMPs) are single pass membrane proteins initially identified by their ability to determine the pharmacology of the calcitonin receptor-like receptor (CLR), a family B G protein-coupled receptor (GPCR). It is now known that RAMPs can interact with a much wider range of GPCRs. This review considers recent developments on the structure of the complexes formed between the extracellular domains (ECDs) of CLR and RAMP1 or RAMP2 as these provide insights as to how the RAMPs direct ligand binding. The range of RAMP interactions is also considered; RAMPs can interact with numerous family B GPCRs as well as examples of family A and family C GPCRs. They influence receptor expression at the cell surface, trafficking, ligand binding and G protein coupling. The GPCR–RAMP interface offers opportunities for drug targeting, illustrated by examples of drugs developed for migraine.

Item Type: Article
Uncontrolled Keywords: adrenomedullin,amylin,calcitonin gene-related peptide (CGRP),calcitonin receptor,calcitonin receptor-like receptor,family B G protein-coupled receptor,receptor activity-modifying protein (RAMP),Biochemistry
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Science and Health > Life Sciences, School of
Depositing User: Jim Jamieson
Date Deposited: 12 Jul 2016 14:39
Last Modified: 06 Sep 2019 19:15

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