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The relationship of seminal transforming growth factor-β1 and interleukin-18 with reproductive success in women exposed to seminal plasma during IVF/ICSI treatment

Nikolaeva, MA and Babayan, AA and Stepanova, EO and Smolnikova, VY and Kalinina, EA and Fernández, N and Krechetova, LV and Vanko, LV and Sukhikh, GT (2016) 'The relationship of seminal transforming growth factor-β1 and interleukin-18 with reproductive success in women exposed to seminal plasma during IVF/ICSI treatment.' Journal of Reproductive Immunology, 117. 45 - 51. ISSN 0165-0378

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Abstract

© 2016 Elsevier Ireland Ltd It has been proposed that the transforming growth factor (TGF)-β1 present in seminal plasma (SP) triggers a female immune response favorable for implantation. We hypothesize that seminal interleukin (IL)-18, a cytokine that can potentially cause implantation failure, interferes with the beneficial effect of TGF-β1. This study aims to determine whether the levels of seminal TGF-β1 and IL-18 are associated with reproductive outcomes in patients exposed to SP during in vitro fertilization (IVF) or IVF with intracytoplasmic sperm injection (ICSI). A prospective study, which included 71 couples undergoing IVF/ICSI was carried out. Female patients were exposed to their partners’ SP via timed intercourse before the day of ovum pick-up (OPU) and also subjected to intravaginal SP application just after OPU. Quantitative measurements of total TGF-β1 (active plus latent) as well as IL-18 were determined by FlowCytomix™ technology in the SP to be used for intravaginal applications. Comparison of SP cytokine profiles between pregnant and non-pregnant groups revealed that pregnancy was correlated with a lower concentration of IL-18 (P = 0.018) and lower content per ejaculate for both of IL-18 (P = 0.0003) and TGF-β1 (P = 0.047). The ratio of TGF-β1-to-IL-18 concentration was significantly higher in the pregnant than in the non-pregnant group (P = 0.026). This study supports the notion that two key cytokines TGF-β1 and IL-18, both present in SP are associated with reproductive outcomes in female patients exposed to SP during IVF/ICSI treatment.

Item Type: Article
Subjects: Q Science > QH Natural history > QH301 Biology
R Medicine > RG Gynecology and obstetrics
Divisions: Faculty of Science and Health > Biological Sciences, School of
Depositing User: Jim Jamieson
Date Deposited: 12 Jul 2016 08:25
Last Modified: 22 Jan 2019 22:16
URI: http://repository.essex.ac.uk/id/eprint/17238

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