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Increased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimer's disease brain

Smith, Adam R and Smith, Rebecca G and Condliffe, Daniel and Hannon, Eilis and Schalkwyk, Leonard and Mill, Jonathan and Lunnon, Katie (2016) 'Increased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimer's disease brain.' Neurobiology of Aging, 47. pp. 35-40. ISSN 0197-4580

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Abstract

Although mutations within the TREM2 gene have been robustly associated with Alzheimer's disease, it is not known whether alterations in the regulation of this gene are also involved in pathogenesis. Here, we present data demonstrating increased DNA methylation in the superior temporal gyrus in Alzheimer's disease brain at a CpG site located 289 bp upstream of the transcription start site of the TREM2 gene in 3 independent study cohorts using 2 different technologies (Illumina Infinium 450K methylation beadchip and pyrosequencing). A meta-analysis across all 3 cohorts reveals consistent AD-associated hypermethylation (p = 3.47E-08). This study highlights that extending genetic studies of TREM2 in AD to investigate epigenetic changes may nominate additional mechanisms by which disruption to this gene increases risk.

Item Type: Article
Uncontrolled Keywords: TREM2; Alzheimer's disease; Braak stage; DNA methylation; Epigenetics; AD; Brain
Subjects: Q Science > QH Natural history > QH426 Genetics
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Faculty of Science and Health
Faculty of Science and Health > Life Sciences, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 22 Jul 2016 14:25
Last Modified: 15 Jan 2022 00:32
URI: http://repository.essex.ac.uk/id/eprint/17295

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