Research Repository

FcΥRIIa genotype is associated with acute coronary syndromes as first manifestation of coronary artery disease

Raaz, D and Herrmann, M and Ekici, AB and Klinghammer, L and Lausen, B and Voll, RE and Leusen, JHW and van de Winkel, JGJ and Daniel, WG and Reis, A and Garlichs, CD (2009) 'FcΥRIIa genotype is associated with acute coronary syndromes as first manifestation of coronary artery disease.' Atherosclerosis, 205 (2). 512 - 516. ISSN 0021-9150

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Abstract

Objective - Identification of clinically relevant determinants for acute coronary syndromes (ACS) promises reduction of ACS-associated mortality. C-reactive protein (CRP) has proved to be useful identifying people at risk for cardiovascular events. However, it is unknown whether genetic variants at Fc? receptor IIa (Fc?RIIa), the main receptor for CRP, are involved in CRP-related cardiovascular risk. We evaluated the potential impact of Fc?RIIa through a genetic association study in patients with ACS. Methods and results - We conducted a genetic association study among 701 consecutive patients with first event of ACS compared to 467 patients with stable angina pectoris. All patients were genotyped for a frequent functional variant at position 131 of the mature Fc?RIIa, where the arginine (R) allele results in an increased signal transduction upon CRP binding. In our study, the R/R131 genotype was significantly associated with ACS as the first manifestation of coronary artery disease (P = 1.2 � 10?9, odds ratio 2.86, 95% CI: 2.06?3.99) compared to the non-R/R131 genotype. Conclusions - Our data show a genetic association of the Fc?RIIa R/R131 genotype with a more frequent occurrence of ACS as the first manifestation of coronary artery disease, probably mediated via its interaction with CRP. Genotyping of this Fc?RIIa variant could help to improve risk stratification in the course of coronary disease in the future.

Item Type: Article
Subjects: Q Science > QA Mathematics
R Medicine > R Medicine (General)
Divisions: Faculty of Science and Health > Mathematical Sciences, Department of
Depositing User: Jim Jamieson
Date Deposited: 12 Dec 2011 11:30
Last Modified: 06 Feb 2018 12:15
URI: http://repository.essex.ac.uk/id/eprint/1761

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