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Architecture and roles of periplasmic adaptor proteins in tripartite efflux assemblies.

Symmons, Martyn F and Marshall, Robert L and Bavro, Vassiliy N (2015) 'Architecture and roles of periplasmic adaptor proteins in tripartite efflux assemblies.' Frontiers in Microbiology, 6 (MAY). 513-. ISSN 1664-302X

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Recent years have seen major advances in the structural understanding of the different components of tripartite efflux assemblies, which encompass the multidrug efflux (MDR) pumps and type I secretion systems. The majority of these investigations have focused on the role played by the inner membrane transporters and the outer membrane factor (OMF), leaving the third component of the system - the Periplasmic Adaptor Proteins (PAPs) - relatively understudied. Here we review the current state of knowledge of these versatile proteins which, far from being passive linkers between the OMF and the transporter, emerge as active architects of tripartite assemblies, and play diverse roles in the transport process. Recognition between the PAPs and OMFs is essential for pump assembly and function, and targeting this interaction may provide a novel avenue for combating multidrug resistance. With the recent advances elucidating the drug efflux and energetics of the tripartite assemblies, the understanding of the interaction between the OMFs and PAPs is the last piece remaining in the complete structure of the tripartite pump assembly puzzle.

Item Type: Article
Uncontrolled Keywords: periplasmic adaptor proteins; TolC; drug efflux pumps; type I secretion system; antibiotic resistance; membrane proteins; membrane transport; RND family pumps
Subjects: Q Science > QR Microbiology
Divisions: Faculty of Science and Health
Faculty of Science and Health > Life Sciences, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 15 Dec 2016 14:22
Last Modified: 18 Aug 2022 11:34

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