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Design and synthesis of 5-aminolaevulinic acid/3-hydroxypyridinone conjugates for photodynamic therapy: enhancement of protoporphyrin IX production and photo-toxicity in tumor cells

Zhou, Tao and Shao, Le-Le and Battah, Sinan and Zhu, Chun-Feng and Hider, Robert C and Reeder, Brandon J and Jabeen, Asma and MacRobert, Alexander J and Ren, Gerui and Liang, Xinle (2016) 'Design and synthesis of 5-aminolaevulinic acid/3-hydroxypyridinone conjugates for photodynamic therapy: enhancement of protoporphyrin IX production and photo-toxicity in tumor cells.' MedChemComm, 7 (6). pp. 1190-1196. ISSN 2040-2503

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Abstract

<p>A series of ALA-HPO conjugates was prepared. One such conjugate was found to possess high phototoxicity.</p>

Item Type: Article
Subjects: Q Science > QD Chemistry
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculty of Science and Health
Faculty of Science and Health > Life Sciences, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 12 Dec 2016 13:44
Last Modified: 06 Jan 2022 14:41
URI: http://repository.essex.ac.uk/id/eprint/18144

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