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The importance of p53 pathway genetics in inherited and somatic cancer genomes

Stracquadanio, Giovanni and Wang, Xuting and Wallace, Marsha D and Grawenda, Anna M and Zhang, Ping and Hewitt, Juliet and Zeron-Medina, Jorge and Castro-Giner, Francesc and Tomlinson, Ian P and Goding, Colin R and Cygan, Kamil J and Fairbrother, William G and Thomas, Laurent F and Sætrom, Pål and Gemignani, Federica and Landi, Stefano and Schuster-Böckler, Benjamin and Bell, Douglas A and Bond, Gareth L (2016) 'The importance of p53 pathway genetics in inherited and somatic cancer genomes.' Nature Reviews Cancer, 16 (4). 251 - 265. ISSN 1474-175X

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Abstract

Decades of research have shown that mutations in the p53 stress response pathway affect the incidence of diverse cancers more than mutations in other pathways. However, most evidence is limited to somatic mutations and rare inherited mutations. Using newly abundant genomic data, we demonstrate that commonly inherited genetic variants in the p53 pathway also affect the incidence of a broad range of cancers more than variants in other pathways. The cancer-associated single nucleotide polymorphisms (SNPs) of the p53 pathway have strikingly similar genetic characteristics to well-studied p53 pathway cancer-causing somatic mutations. Our results enable insights into p53-mediated tumour suppression in humans and into p53 pathway-based cancer surveillance and treatment strategies.

Item Type: Article
Subjects: Q Science > QA Mathematics > QA75 Electronic computers. Computer science
Q Science > QH Natural history > QH426 Genetics
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculty of Science and Health > Computer Science and Electronic Engineering, School of
Depositing User: Giovanni Stracquadanio
Date Deposited: 09 Jan 2017 16:43
Last Modified: 02 Aug 2018 12:15
URI: http://repository.essex.ac.uk/id/eprint/18687

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