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Design of robust metabolic pathways

Umeton, Renato and Stracquadanio, Giovanni and Sorathiya, Anilkumar and Liò, Pietro and Papini, Alessio and Nicosia, Giuseppe (2011) Design of robust metabolic pathways. In: the 48th Design Automation Conference, 2011-06-05 - 2011-06-10.

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In this paper we investigate plant photosynthesis and microbial fuel cells. We report the following: 1) we introduce and validate a novel multi-objective optimization algorithm, PMO2; 2) in photosynthesis we increase the yield of 135%, while in Geobacter sulfurreducens we determine the tradeoff for growth versus redox properties; 3) finally, we discuss Pareto-Front as an estimator of robust metabolic pathways. © 2011 ACM.

Item Type: Conference or Workshop Item (Paper)
Additional Information: Published proceedings: Proceedings - Design Automation Conference
Uncontrolled Keywords: Metabolic engineering; Mutational Robustness; Geobacter sulfurreducens; Carbon metabolism; Multi-objective Optimization
Subjects: Q Science > QA Mathematics > QA75 Electronic computers. Computer science
Divisions: Faculty of Science and Health
Faculty of Science and Health > Computer Science and Electronic Engineering, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 13 Feb 2017 13:33
Last Modified: 15 Jan 2022 00:39

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