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Generalized Pattern Search and Mesh Adaptive Direct Search Algorithms for Protein Structure Prediction

Nicosia, Giuseppe and Stracquadanio, Giovanni (2007) Generalized Pattern Search and Mesh Adaptive Direct Search Algorithms for Protein Structure Prediction. In: UNSPECIFIED, ? - ?.

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Abstract

Proteins are the most important molecular entities of a living organism and understanding their functions is an important task to treat diseases and synthesize new drugs. It is largely known that the function of a protein is strictly related to its spatial conformation: to tackle this problem, we have proposed a new approach based on a class of pattern search algorithms that is largely used in optimization of real world applications. The obtained results are interesting in terms of the quality of the structures (RMSD-C α) and energy values found. © Springer-Verlag Berlin Heidelberg 2007.

Item Type: Conference or Workshop Item (UNSPECIFIED)
Additional Information: Published proceedings: Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Uncontrolled Keywords: protein folding; pattern search algorithms; non-linear optimization
Subjects: Q Science > QA Mathematics > QA75 Electronic computers. Computer science
Divisions: Faculty of Science and Health
Faculty of Science and Health > Computer Science and Electronic Engineering, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 13 Feb 2017 15:05
Last Modified: 15 Jan 2022 00:39
URI: http://repository.essex.ac.uk/id/eprint/18718

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