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A Neural “Tuning Curve” for Multisensory Experience and Cognitive-Perceptual Schizotypy

Ferri, F and Nikolova, Y and Perrrucci, M and Costantini, M and Ferretti, A and Gatta, V and Huang, Z and Edden, R and Qiang, Y and D'Aurora, M and Sibille, E and Stuppia, L and Romani, GL and Northoff, G (2017) 'A Neural “Tuning Curve” for Multisensory Experience and Cognitive-Perceptual Schizotypy.' Schizophrenia Bulletin, 43 (4). 801 - 813. ISSN 0586-7614

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Abstract

Our coherent perception of external events is enabled by the integration of inputs from different senses occurring within a range of temporal offsets known as the temporal binding window (TBW), which varies from person to person. A relatively wide TBW may increase the likelihood that stimuli originating from different environmental events are erroneously integrated and abnormally large TBW has been found in psychiatric disorders characterized by unusual perceptual experiences. Despite strong evidence of interindividual differences in TBW, both within clinical and nonclinical populations, the neurobiological underpinnings of this variability remain unclear. We adopted an integrated strategy linking TBW to temporal dynamics in functional magnetic resonance imaging (fMRI)-resting-state activity and cortical excitation/inhibition (E/I) balance, indexed by glutamate/Gamma-AminoButyric Acid (GABA) concentrations and common variation in glutamate and GABA genes in a healthy sample. Stronger resting-state longrange temporal correlations, indicated by larger power law exponent (PLE), in the auditory cortex, robustly predicted narrower audio-tactile TBW, which was in turn associated with lower cognitive-perceptual schizotypy. Furthermore, PLE was highest and TBW narrowest for individuals with intermediate levels of E/I balance, with shifts towards either extreme resulting in reduced multisensory temporal precision and increased schizotypy, effectively forming a neural ?tuning curve? for multisensory experience and schizophrenia risk. Our findings shed light on the neurobiological underpinnings of multisensory integration and its potentially clinically relevant inter-individual variability.

Item Type: Article
Uncontrolled Keywords: schizotypy, multisensory perception, functional magnetic resonance imaging (fMRI) resting-state activity, long-range temporal correlations, excitation, inhibition balance, GABA (gamma-amminobutyric acid), glutamate, multilocus genetic score
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RA Public aspects of medicine > RA790 Mental Health
Divisions: Faculty of Science and Health > Psychology, Department of
Depositing User: Francesca Ferri
Date Deposited: 05 Jan 2017 12:20
Last Modified: 05 Mar 2018 17:15
URI: http://repository.essex.ac.uk/id/eprint/18729

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