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Advances in genetics: widening our understanding of prostate cancer

Pine, Angela C and Fioretti, Flavia F and Brooke, Greg N and Bevan, Charlotte L (2016) 'Advances in genetics: widening our understanding of prostate cancer.' F1000Research, 5. p. 1512. ISSN 2046-1402

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Abstract

<ns4:p>Prostate cancer is a leading cause of cancer-related death in Western men. Our understanding of the genetic alterations associated with disease predisposition, development, progression, and therapy response is rapidly improving, at least in part, owing to the development of next-generation sequencing technologies. Large advances have been made in our understanding of the genetics of prostate cancer through the application of whole-exome sequencing, and this review summarises recent advances in this field and discusses how exome sequencing could be used clinically to promote personalised medicine for prostate cancer patients.</ns4:p>

Item Type: Article
Uncontrolled Keywords: Androgen; Cancer progression; DNA damage repair; Metastasis; Personalised Medicine; Prostate Cancer; Transcriptome; WES; Whole Exome Sequencing
Subjects: Q Science > QH Natural history > QH301 Biology
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculty of Science and Health
Faculty of Science and Health > Life Sciences, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 18 Jan 2017 14:15
Last Modified: 06 Jan 2022 14:44
URI: http://repository.essex.ac.uk/id/eprint/18810

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