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Advanced paternal age effects in neurodevelopmental disorders-review of potential underlying mechanisms

Janecka, M and Mill, J and Basson, MA and Goriely, A and Spiers, H and Reichenberg, A and Schalkwyk, L and Fernandes, C (2017) 'Advanced paternal age effects in neurodevelopmental disorders-review of potential underlying mechanisms.' Translational Psychiatry, 7 (1). ISSN 2158-3188

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Abstract

© The Author(s) 2017. Multiple epidemiological studies suggest a relationship between advanced paternal age (APA) at conception and adverse neurodevelopmental outcomes in offspring, particularly with regard to increased risk for autism and schizophrenia. Conclusive evidence about how age-related changes in paternal gametes, or age-independent behavioral traits affect neural development is still lacking. Recent evidence suggests that the origins of APA effects are likely to be multidimensional, involving both inherited predisposition and de novo events. Here we provide a review of the epidemiological and molecular findings to date. Focusing on the latter, we present the evidence for genetic and epigenetic mechanisms underpinning the association between late fatherhood and disorder in offspring. We also discuss the limitations of the APA literature. We propose that different hypotheses relating to the origins of the APA effects are not mutually exclusive. Instead, multiple mechanisms likely contribute, reflecting the etiological complexity of neurodevelopmental disorders.

Item Type: Article
Subjects: Q Science > QH Natural history > QH426 Genetics
Divisions: Faculty of Science and Health > Biological Sciences, School of
Depositing User: Jim Jamieson
Date Deposited: 03 Feb 2017 13:27
Last Modified: 11 Dec 2017 17:15
URI: http://repository.essex.ac.uk/id/eprint/18968

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