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Recent structural insights into the function of copper nitrite reductases.

Horrell, S and Kekilli, D and Strange, RW and Hough, MA (2017) 'Recent structural insights into the function of copper nitrite reductases.' Metallomics, 9 (11). pp. 1470-1482. ISSN 1756-5901

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Copper nitrite reductases (CuNiR) carry out the first committed step of the denitrification pathway of the global nitrogen cycle, the reduction of nitrite (NO2(-)) to nitric oxide (NO). As such, they are of major agronomic and environmental importance. CuNiRs occur primarily in denitrifying soil bacteria which carry out the overall reduction of nitrate to dinitrogen. In this article, we review the insights gained into copper nitrite reductase (CuNiR) function from three dimensional structures. We particularly focus on developments over the last decade, including insights from serial femtosecond crystallography using X-ray free electron lasers (XFELs) and from the recently discovered 3-domain CuNiRs.

Item Type: Article
Uncontrolled Keywords: Nitrites; Copper; Nitric Oxide; Nitrite Reductases; Bacterial Proteins; Crystallography, X-Ray; Protein Binding; Electron Transport; Models, Molecular; Protein Domains
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Science and Health
Faculty of Science and Health > Life Sciences, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 04 Aug 2017 15:45
Last Modified: 18 Aug 2022 13:07

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