Research Repository

Multidrug Efflux in the Context of Two-Membrane Cell Envelopes

Zgurskaya, Helen I and Bavro, Vassiliy N and Weeks, Jon W and Krishnamoorthy, Ganesh (2016) 'Multidrug Efflux in the Context of Two-Membrane Cell Envelopes.' In: Li, Xian-Zhi and Elkins, Christopher and Zgurskaya, Helen I, (eds.) Efflux-Mediated Antimicrobial Resistance in Bacteria. Springer, 99 - 128. ISBN 978-3-319-39656-9

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The trans-envelope drug efflux in Gram-negative bacteria demands assembly of specialized protein complexes that in addition to inner membrane transporters include periplasmic membrane fusion proteins and outer membrane channels due to the presence of a double membrane. These complexes are highly versatile and constitute a major antimicrobial resistance mechanism of Gram-negative bacteria. The modular organization of the tripartite assemblies in Gram-negative bacteria allows them to accommodate a wide array of multidrug efflux transporters enabling efflux across both the inner and the outer membranes of the cell envelope. This chapter focuses on the structures and mechanisms of trans-envelope multidrug efflux pumps from Gram-negative bacteria. We summarize the current state of the field and the emerging model for multidrug efflux in the context of two membranes.

Item Type: Book Section
Uncontrolled Keywords: Gram-negative bacteria; Multidrug resistance; Multidrug efflux pump; Cytoplasmic (inner) membrane; Outer membrane; Outer membrane factor; Membrane fusion protein; AcrAB; MacAB; TolC; MexAB-OprM
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Science and Health > Life Sciences, School of
Depositing User: Elements
Date Deposited: 12 Oct 2017 13:09
Last Modified: 28 Jun 2021 13:15

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