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Novel and divergent genes in the evolution of placental mammals.

Dunwell, TL and Paps, J and Holland, PWH (2017) 'Novel and divergent genes in the evolution of placental mammals.' Proceedings of the Royal Society B: Biological Sciences, 284 (1864). p. 20171357. ISSN 0962-8452

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Analysis of genome sequences within a phylogenetic context can give insight into the mode and tempo of gene and protein evolution, including inference of gene ages. This can reveal whether new genes arose on particular evolutionary lineages and were recruited for new functional roles. Here, we apply MCL clustering with all-versus-all reciprocal BLASTP to identify and phylogenetically date 'Homology Groups' among vertebrate proteins. Homology Groups include new genes and highly divergent duplicate genes. Focusing on the origin of the placental mammals within the Eutheria, we identify 357 novel Homology Groups that arose on the stem lineage of Placentalia, 87 of which are deduced to play core roles in mammalian biology as judged by extensive retention in evolution. We find the human homologues of novel eutherian genes are enriched for expression in preimplantation embryo, brain, and testes, and enriched for functions in keratinization, reproductive development, and the immune system.

Item Type: Article
Uncontrolled Keywords: New genes; molecular evolution; MCL clustering; Eutheria; Placentalia
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Science and Health
Faculty of Science and Health > Life Sciences, School of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 18 Oct 2017 11:08
Last Modified: 18 Aug 2022 10:47

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