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Vitamin D and cognitive function: A Mendelian randomisation study

Maddock, J and Zhou, A and Cavadino, A and Kuźma, E and Bao, Y and Smart, MC and Saum, KU and Schöttker, B and Engmann, J and Kjærgaard, M and Karhunen, V and Zhan, Y and Lehtimäki, T and Rovio, SP and Byberg, L and Lahti, J and Marques-Vidal, P and Sen, A and Perna, L and Schirmer, H and Singh-Manoux, A and Auvinen, J and Hutri-Kähönen, N and Kähönen, M and Kilander, L and Räikkönen, K and Melhus, H and Ingelsson, E and Guessous, I and Petrovic, KE and Schmidt, H and Schmidt, R and Vollenweider, P and Lind, L and Eriksson, JG and Michaëlsson, K and Raitakari, OT and Hägg, S and Pedersen, NL and Herzig, KH and Järvelin, MR and Veijola, J and Kivimaki, M and Jorde, R and Brenner, H and Kumari, M and Power, C and Llewellyn, DJ and Hyppönen, E (2017) 'Vitamin D and cognitive function: A Mendelian randomisation study.' Scientific Reports, 7 (1). ISSN 2045-2322

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Abstract

The causal nature of the association between hypovitaminosis D and poor cognitive function in mid- to later-life is uncertain. Using a Mendelian randomisation(MR) approach, we examined the causal relationship between 25(OH)D and cognitive function. Data came from 172,349 participants from 17 cohorts. DHCR7(rs12785878), CYP2R1 rs12794714) and their combined synthesis score were chosen to proxy 25(OH)D. Cognitive tests were standardised into global and memory scores. Analyses were stratified by 25(OH)D tertiles, sex and age. Random effects meta-analyses assessed associations between 25(OH)D and cognitive function. Associations of serum 25(OH)D with global and memory-related cognitive function were non-linear (lower cognitive scores for both low and high 25(OH)D, p curvature ≤ 0.006), with much of the curvature attributed to a single study. DHCR7, CYP2R1, and the synthesis score were associated with small reductions in 25(OH)D per vitamin D-decreasing allele. However, coefficients for associations with global or memory-related cognitive function were non-significant and in opposing directions for DHCR7 and CYP2R1, with no overall association observed for the synthesis score. Coefficients for the synthesis score and global and memory cognition were similar when stratified by 25(OH)D tertiles, sex and age. We found no evidence for serum 25(OH)D concentration as a causal factor for cognitive performance in mid- to later life.

Item Type: Article
Subjects: H Social Sciences > H Social Sciences (General)
R Medicine > R Medicine (General)
Divisions: Faculty of Social Sciences > Institute for Social and Economic Research
Depositing User: Elements
Date Deposited: 17 Nov 2017 12:26
Last Modified: 17 Nov 2017 12:26
URI: http://repository.essex.ac.uk/id/eprint/20677

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