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Genome-wide association study of male sexual orientation

Sanders, AR and Beecham, GW and Guo, S and Dawood, K and Rieger, G and Badner, JA and Gershon, ES and Krishnappa, RS and Kolundzija, AB and Duan, J and Shi, J and Levinson, DF and Mowry, BJ and Olincy, A and Amin, F and Cloninger, CR and Svrakic, DM and Silverman, JM and Buccola, NG and Byerley, WF and Black, DW and Freedman, R and Gejman, PV and Bailey, JM and Martin, ER (2017) 'Genome-wide association study of male sexual orientation.' Scientific Reports, 7 (1). ISSN 2045-2322

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Abstract

Family and twin studies suggest that genes play a role in male sexual orientation. We conducted a genome-wide association study (GWAS) of male sexual orientation on a primarily European ancestry sample of 1,077 homosexual men and 1,231 heterosexual men using Affymetrix single nucleotide polymorphism (SNP) arrays. We identified several SNPs with p < 10 -5 , including regions of multiple supporting SNPs on chromosomes 13 (minimum p = 7.5 × 10 -7 ) and 14 (p = 4.7 × 10 -7 ). The genes nearest to these peaks have functions plausibly relevant to the development of sexual orientation. On chromosome 13, SLITRK6 is a neurodevelopmental gene mostly expressed in the diencephalon, which contains a region previously reported as differing in size in men by sexual orientation. On chromosome 14, TSHR genetic variants in intron 1 could conceivably help explain past findings relating familial atypical thyroid function and male homosexuality. Furthermore, skewed X chromosome inactivation has been found in the thyroid condition, Graves' disease, as well as in mothers of homosexual men. On pericentromeric chromosome 8 within our previously reported linkage peak, we found support (p = 4.1 × 10 -3 ) for a SNP association previously reported (rs77013977, p = 7.1 × 10 -8 ), with the combined analysis yielding p = 6.7 × 10 -9 , i.e., a genome-wide significant association.

Item Type: Article
Subjects: B Philosophy. Psychology. Religion > BF Psychology
Divisions: Faculty of Science and Health > Psychology, Department of
Depositing User: Elements
Date Deposited: 06 Mar 2018 14:28
Last Modified: 06 Mar 2018 15:15
URI: http://repository.essex.ac.uk/id/eprint/20862

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