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Metabolic Profiling of Adiponectin Levels in Adults

Borges, Maria Carolina and Barros, Aluísio JD and Ferreira, Diana L Santos and Casas, Juan Pablo and Horta, Bernardo Lessa and Kivimaki, Mika and Kumari, Meena and Menon, Usha and Gaunt, Tom R and Ben-Shlomo, Yoav and Freitas, Deise F and Oliveira, Isabel O and Gentry-Maharaj, Aleksandra and Fourkala, Evangelia and Lawlor, Debbie A and Hingorani, Aroon D (2017) 'Metabolic Profiling of Adiponectin Levels in Adults.' Circulation: Cardiovascular Genetics, 10 (6). e001837-. ISSN 1942-325X

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Background - Adiponectin, a circulating adipocyte-derived protein, has insulin-sensitizing, anti-inflammatory, antiatherogenic, and cardiomyocyte-protective properties in animal models. However, the systemic effects of adiponectin in humans are unknown. Our aims were to define the metabolic profile associated with higher blood adiponectin concentration and investigate whether variation in adiponectin concentration affects the systemic metabolic profile. Methods and Results - We applied multivariable regression in ≤5909 adults and Mendelian randomization (using cis-acting genetic variants in the vicinity of the adiponectin gene as instrumental variables) for analyzing the causal effect of adiponectin in the metabolic profile of ≤37 545 adults. Participants were largely European from 6 longitudinal studies and 1 genome-wide association consortium. In the multivariable regression analyses, higher circulating adiponectin was associated with higher high-density lipoprotein lipids and lower very-low-density lipoprotein lipids, glucose levels, branched-chain amino acids, and inflammatory markers. However, these findings were not supported by Mendelian randomization analyses for most metabolites. Findings were consistent between sexes and after excluding high-risk groups (defined by age and occurrence of previous cardiovascular event) and 1 study with admixed population. Conclusions - Our findings indicate that blood adiponectin concentration is more likely to be an epiphenomenon in the context of metabolic disease than a key determinant.

Item Type: Article
Uncontrolled Keywords: adiponectin; cardiovascular disease; insulin; Mendelian Randomization Analysis; metabolism; metabolomics
Subjects: H Social Sciences > H Social Sciences (General)
R Medicine > R Medicine (General)
Divisions: Faculty of Social Sciences
Faculty of Social Sciences > Institute for Social and Economic Research
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 06 Sep 2018 12:54
Last Modified: 18 Aug 2022 10:53

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