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Duration of depressive symptoms and mortality risk: The English Longitudinal Study of Ageing (ELSA)

White, James and Zaninotto, Paola and Walters, Kate and Kivimäki, Mika and Demakakos, Panayotes and Biddulph, Jane and Kumari, Meena and De Oliveira, Cesar and Gallacher, John and Batty, G David (2016) 'Duration of depressive symptoms and mortality risk: The English Longitudinal Study of Ageing (ELSA).' British Journal of Psychiatry, 208 (04). 337 - 342. ISSN 0007-1250

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Abstract

Background The relationship between the duration of depressive symptoms and mortality remains poorly understood. Aims To examine whether the duration of depressive symptoms is associated with mortality risk. Method Data (n = 9560) came from the English Longitudinal Study of Ageing (ELSA). We assessed depressive symptom duration as the sum of examinations with an eight-item Center for Epidemiologic Studies Depression Scale score of ⩾3; we ascertained mortality from linking our data to a national register. Results Relative to those participants who never reported symptoms, the age- and gender-adjusted hazard ratios for elevated depressive symptoms over 1, 2, 3 and 4 examinations were 1.41 (95% CI 1.15–1.74), 1.80 (95% CI 1.44–2.26), 1.97 (95% CI 1.57–2.47) and 2.48 (95% CI 1.90–3.23), respectively (P for trend <0.001). This graded association can be explained largely by differences in physical activity, cognitive function, functional impairments and physical illness. Conclusions In this cohort of older adults, the duration of depressive symptoms was associated with mortality in a dose–response manner.

Item Type: Article
Subjects: H Social Sciences > H Social Sciences (General)
R Medicine > RA Public aspects of medicine > RA790 Mental Health
Divisions: Faculty of Social Sciences > Institute for Social and Economic Research
Depositing User: Elements
Date Deposited: 12 Nov 2018 10:29
Last Modified: 12 Nov 2018 10:29
URI: http://repository.essex.ac.uk/id/eprint/23458

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