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Strengthening functionally specific neural pathways with transcranial brain stimulation

Chiappini, Emilio and Silvanto, Juha and Hibbard, Paul B and Avenanti, Alessio and Romei, Vincenzo (2018) 'Strengthening functionally specific neural pathways with transcranial brain stimulation.' Current Biology, 28 (13). R735-R736. ISSN 0960-9822

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Cortico-cortical paired associative stimulation (ccPAS) is a recently established offline dual-coil transcranial magnetic stimulation (TMS) protocol 1, 2, 3 based on the Hebbian principle of associative plasticity and designed to transiently enhance synaptic efficiency in neural pathways linking two interconnected (targeted) brain regions 4, 5. Here, we present a new ‘function-tuning ccPAS’ paradigm in which, by pairing ccPAS with the presentation of a specific visual feature, for example a specific motion direction, we can selectively target and enhance the synaptic efficiency of functionally specific, but spatially overlapping, pathways. We report that ccPAS applied in a state-dependent manner and at a low intensity selectively enhanced detection of the specific motion direction primed during the combined visual-TMS manipulations. This paradigm significantly enhances the specificity of TMS-induced plasticity, by allowing the targeting of cortico-cortical pathways associated with specific functions.

Item Type: Article
Uncontrolled Keywords: Visual Cortex; Neural Pathways; Humans; Adult; Female; Male; Transcranial Magnetic Stimulation; Young Adult
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Faculty of Science and Health
Faculty of Science and Health > Psychology, Department of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 23 Nov 2018 15:12
Last Modified: 18 Aug 2022 13:13

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