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Assessing potential shared genetic aetiology between body mass index and sleep duration in 142,209 individuals

Garfield, Victoria and Fatemifar, Ghazaleh and Dale, Caroline and Smart, Melissa and Bao, Yanchun and Llewellyn, Clare H and Steptoe, Andrew and Zabaneh, Delilah and Kumari, Meena (2019) 'Assessing potential shared genetic aetiology between body mass index and sleep duration in 142,209 individuals.' Genetic Epidemiology, 43 (2). pp. 207-214. ISSN 0741-0395

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Observational studies find an association between increased body mass index (BMI) and short self‐reported sleep duration in adults. However, the underlying biological mechanisms that underpin these associations are unclear. Recent findings from the UK Biobank suggest a weak genetic correlation between BMI and self‐reported sleep duration. However, the potential shared genetic aetiology between these traits has not been examined using a comprehensive approach. To investigate this, we created a polygenic risk score (PRS) of BMI and examined its association with self‐reported sleep duration in a combination of individual participant data and summary‐level data, with a total sample size of 142,209 individuals. Although we observed a nonsignificant genetic correlation between BMI and sleep duration, using LD score regression (rg = −0.067 [SE = 0.039], P = 0.092) we found that a PRS of BMI is associated with a decrease in sleep duration (unstandardized coefficient = −1.75 min [SE = 0.67], P = 6.13 × 10−7), but explained only 0.02% of the variance in sleep duration. Our findings suggest that BMI and self‐reported sleep duration possess a small amount of shared genetic aetiology and other mechanisms must underpin these associations.

Item Type: Article
Uncontrolled Keywords: body mass index; genetic correlation; polygenic risk score; sleep duration
Subjects: Q Science > QH Natural history > QH426 Genetics
Divisions: Faculty of Science and Health
Faculty of Science and Health > Mathematical Sciences, Department of
Faculty of Social Sciences
Faculty of Social Sciences > Institute for Social and Economic Research
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 10 Dec 2018 10:17
Last Modified: 06 Jan 2022 13:56

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