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Brain-actuated functional electrical stimulation elicits lasting arm motor recovery after stroke

Biasiucci, A and Leeb, R and Iturrate, I and Perdikis, S and Al-Khodairy, A and Corbet, T and Schnider, A and Schmidlin, T and Zhang, H and Bassolino, M and Viceic, D and Vuadens, P and Guggisberg, AG and Millán, JDR (2018) 'Brain-actuated functional electrical stimulation elicits lasting arm motor recovery after stroke.' Nature Communications, 9 (1). ISSN 2041-1723

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Abstract

Brain-computer interfaces (BCI) are used in stroke rehabilitation to translate brain signals into intended movements of the paralyzed limb. However, the efficacy and mechanisms of BCI-based therapies remain unclear. Here we show that BCI coupled to functional electrical stimulation (FES) elicits significant, clinically relevant, and lasting motor recovery in chronic stroke survivors more effectively than sham FES. Such recovery is associated to quantitative signatures of functional neuroplasticity. BCI patients exhibit a significant functional recovery after the intervention, which remains 6–12 months after the end of therapy. Electroencephalography analysis pinpoints significant differences in favor of the BCI group, mainly consisting in an increase in functional connectivity between motor areas in the affected hemisphere. This increase is significantly correlated with functional improvement. Results illustrate how a BCI–FES therapy can drive significant functional recovery and purposeful plasticity thanks to contingent activation of body natural efferent and afferent pathways.

Item Type: Article
Subjects: Q Science > QA Mathematics > QA75 Electronic computers. Computer science
R Medicine > R Medicine (General)
Divisions: Faculty of Science and Health > Computer Science and Electronic Engineering, School of
Depositing User: Elements
Date Deposited: 13 Feb 2019 14:05
Last Modified: 13 Feb 2019 14:05
URI: http://repository.essex.ac.uk/id/eprint/24054

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