Fuskevåg, O M and Brosker, A and Davies, N and Cudmore, T and Hodges, T and Griffin, Murray (2012) Lactobacillus casei Shirota modulation of Ammonia Metabolism in Physical Exercise. International Journal of Probiotics & Prebiotics, 7. pp. 121-125. ISSN 1555-1431Full text not yet available from this repository.
Background: Ammonia is a continuously produced metabolic toxic waste product. Decompensated liver disease patients have elevated ammonia levels and are prone to infection. Increased ammonia levels have been recorded following physical exertion. Mechanisms to control ammonia overspill are limited. Urea cycle disorders receive therapeutic phenylacetate to lower ammonia, captured as glutamine. Bacteria of the genus Lactobacillus synthesise phenylacetate and this may provide a useful mechanism to control ammonia overspill in athletes. A pilot study with male football players investigated the possibility that L. casei Shirota probiotic supplement could naturally generate phenylacetate, and contribute to ammonia removal through glutamine sequestration as phenylacetylglutamine via the kidneys. Methods: Volunteers were assigned to one of two groups: probiotic supplemented (x2/day) or controls. All subjects undertook an exhaustive exercise routine in a 9-station static exercise program. Urine samples were collected 4hr after the exercise program. The program was repeated after 1 month. Urinary phenyacetylglutamine and ammonia, corrected by creatinine levels, were measured. Results: Expressed as the difference in urinary levels between the two sampling points. Phenylacetylglutamine was significantly increased in the probiotic group (P<0.01) ammonia levels were lower compared to the control group (P=0.064). Conclusion: Probiotic Lactobacillus supplementation may be useful in controlling exercise-generated ammonia.
|Subjects:||Q Science > QH Natural history > QH301 Biology
R Medicine > RC Internal medicine > RC1200 Sports Medicine
|Divisions:||Faculty of Science and Engineering > Biological Sciences, School of|
|Depositing User:||Jim Jamieson|
|Date Deposited:||25 May 2012 11:45|
|Last Modified:||28 May 2012 12:55|
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