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Automated segmentation of the optic nerve head for diagnosis of glaucoma

Chrástek, R and Wolf, M and Donath, K and Niemann, H and Paulus, D and Hothorn, T and Lausen, B and Lämmer, R and Mardin, CY and Michelson, G (2005) 'Automated segmentation of the optic nerve head for diagnosis of glaucoma.' Medical Image Analysis, 9 (4). pp. 297-314. ISSN 1361-8415

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Glaucoma is the second most common cause of blindness worldwide. Low awareness and high costs connected to glaucoma are reasons to improve methods of screening and therapy. A well-established method for diagnosis of glaucoma is the examination of the optic nerve head using scanning-laser-tomography. This system acquires and analyzes the surface topography of the optic nerve head. The analysis that leads to a diagnosis of the disease depends on prior manual outlining of the optic nerve head by an experienced ophthalmologist. Our contribution presents a method for optic nerve head segmentation and its validation. The method is based on morphological operations, Hough transform, and an anchored active contour model. The results were validated by comparing the performance of different classifiers on data from a case-control study with contours of the optic nerve head manually outlined by an experienced ophthalmologist. We achieved the following results with respect to glaucoma diagnosis: linear discriminant analysis with 27.7% estimated error rate for automated segmentation (aut) and 26.8% estimated error rate for manual segmentation (man), classification trees with 25.2% (aut) and 22.0% (man) and bootstrap aggregation with 22.2% (aut) and 13.4% (man). It could thus be shown that our approach is suitable for automated diagnosis and screening of glaucoma.

Item Type: Article
Uncontrolled Keywords: Anchored active contour model; Glaucoma; Optic nerve head; Scanning-laser-tomography; Segmentation
Subjects: R Medicine > RE Ophthalmology
Divisions: Faculty of Science and Health
Faculty of Science and Health > Mathematical Sciences, Department of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 13 Jun 2012 10:40
Last Modified: 06 Jan 2022 13:24

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