Research Repository

Diagnostic value of multifocal VEP using cross-validation and noise reduction in glaucoma research

Lindenberg, T and Peters, A and Horn, FK and Lausen, B and Korth, M (2004) 'Diagnostic value of multifocal VEP using cross-validation and noise reduction in glaucoma research.' Graefe's Archive for Clinical and Experimental Ophthalmology, 242 (5). pp. 361-367. ISSN 0721-832X

Full text not available from this repository.


Background The diagnostic value of multifocal visual evoked potentials (mf VEP) in glaucoma research is still under debate. Several previous studies proclaim it to be a useful tool for clinical applications, but according to other studies, different problems (low specificity, poor records, and interindividual variation) still retard its clinical use. The aim of the present study was to examine whether the mf VEP data obtained with the RETIscan system are appropriate for formulating a classification rule for glaucoma. Method We examined and evaluated 65 eyes in 38 advanced glaucoma patients and 27 normal subjects, using four occipital gold cup electrodes (cross layout) for bipolar recording and a CRT monitor (display diameter 60 �, chequerboard pattern reversal, 60 segments in dartboard layout) for stimulation. In each case, eight cumulative measurements (77 s each) were made. The data of the 60 segments were cross-correlated with a RETIscan-internal VEP norm (ldquoVEP finderrdquo), combined in 16 sectors, and evaluated via the classification technique ldquodouble-baggingrdquo and the Wilcoxon U-test. Results In three out of the 16 sectors, the VEP amplitudes of the patients were significantly reduced (Wilcoxon U-test). Applying double-bagging on the cross-correlated data (with VEP finder) resulted in a sensitivity of 75% and a specificity of 71%, and the estimated misclassification rate was 27%. For uncorrelated data (without VEP finder), the same analysis achieved a sensitivity of about 60% and a specificity of 40%. Conclusions Estimated sensitivity and specificity suggest that by using the RETIscan system for recording, a classification of the VEP data?i.e. a separation between normal and glaucoma subjects?is possible.

Item Type: Article
Uncontrolled Keywords: Humans; Vision Disorders; Glaucoma, Open-Angle; Diagnostic Techniques, Ophthalmological; Sensitivity and Specificity; Reproducibility of Results; Predictive Value of Tests; Pattern Recognition, Visual; Evoked Potentials, Visual; Intraocular Pressure; Visual Fields; Biomedical Research; Middle Aged; Female; Male
Subjects: R Medicine > RE Ophthalmology
Divisions: Faculty of Science and Health
Faculty of Science and Health > Mathematical Sciences, Department of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 29 May 2012 13:47
Last Modified: 06 Jan 2022 13:24

Actions (login required)

View Item View Item