Research Repository

Regulation of MAPK function by direct interaction with the mating-specific Gα in yeast

Metodiev, MV and Matheos, D and Rose, MD and Stone, DE (2002) 'Regulation of MAPK function by direct interaction with the mating-specific Gα in yeast.' Science, 296 (5572). 1483 - 1486. ISSN 0036-8075

[img] PDF
Metodiev_Science.pdf - Published Version
Restricted to Repository staff only

Download (245kB)


The mating response of the budding yeast Saccharomyces cerevisiae is mediated by a prototypical heterotrimeric GTP-binding protein (G protein) and mitogen-activated protein kinase (MAPK) cascade. Although signal transmission by such pathways has been modeled in detail, postreceptor down-regulation is less well understood. The pheromone-responsive G protein α subunit (Gα) of yeast down-regulates the mating signal, but its targets are unknown. We have found that Gα binds directly to the mating-specific MAPK in yeast cells responding to pheromone. This interaction contributes both to modulation of the mating signal and to the chemotropic response, and it demonstrates direct communication between the top and bottom of a Gα-MAPK pathway.

Item Type: Article
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Q Science > QR Microbiology
Divisions: Faculty of Science and Health > Life Sciences, School of
Depositing User: Metodi Metodiev
Date Deposited: 17 Jul 2012 09:02
Last Modified: 03 Oct 2019 18:15

Actions (login required)

View Item View Item