Research Repository

Direct and Indirect Classification in Clinical Research

Peters, A and Lausen, B (2003) 'Direct and Indirect Classification in Clinical Research.' Biometrical Journal, 45 (8). pp. 1023-1041. ISSN 0323-3847

Full text not available from this repository.


We investigate if the use of a priori knowledge allows an improvement of medical decision making. We compare two frameworks of classification ? direct and indirect classification ? with respect to different classification errors: differential misclassification, observed misclassification and true misclassification. We analyze general behaviors of the classifiers in an artificial example and furthermore as being interested in the diagnosis of early glaucoma we adapt a simulation model of the optic nerve head. Indirect classifiers outperform direct classifiers in certain parameter situations of a Monte-Carlo study. In summary, we demonstrate that indirect classification provides a flexible framework to improve diagnostic rules by using explicit a priori knowledge in clinical research.

Item Type: Article
Uncontrolled Keywords: Simulation study; Supervised classification; Differential misclassification; Glaucoma
Subjects: H Social Sciences > HA Statistics
Divisions: Faculty of Science and Health
Faculty of Science and Health > Mathematical Sciences, Department of
SWORD Depositor: Elements
Depositing User: Elements
Date Deposited: 19 Jun 2012 13:14
Last Modified: 06 Jan 2022 13:24

Actions (login required)

View Item View Item